Chemotherapy

Depending on the reaction type of the reaction severity, the dose should be decreased and patient status is to be monitored, as mentioned, the regular dose is 3.6mg per kg, If this dose induced some reaction/toxicity, next dose should be 3mg per kg, and the following dose is 2.4mg per kg if another reaction took place with the first dose adjustment, however if the reaction still not controlled with the second dose reduction, the treatment should be discontinued and alternative therapy should be pursued.