It's an antiandrogen medication that is used to treat prostate cancer.
Prostate cancer, metastatic:
Abiraterone selectively and irreversibly inhibits CYP17 , an enzyme required for androgen biosynthesis which is expressed in testicular, adrenal, and prostatic tumor tissues. Inhibits the formation of the testosterone precursors dehydroepiandrosterone (DHEA) and androstenedione.
Zytiga: 1,000 mg once daily (in combination with prednisone 5 mg twice daily)
Yonsa (micronized formulation): 500 mg once daily (in combination with methylprednisolone 4 mg twice daily)
Doesn't require dose adjustment for renal patients.
Patients with currently hepatic impairment; it depends on the severity of the liver status:
Mild: No dosage adjustment necessary.
Moderate : 250 mg once daily (Zytiga) or 125 mg once daily (Yonsa). Permanently discontinue if ALT and/or AST >5 times the ULN or total bilirubin >3 times ULN occur during treatment in patients with baseline moderate hepatic impairment.
Severe: Do not use.
Lexicomp - Drug information handbook
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