About Abiraterone Acetate:

It’s an antiandrogen medication that is used to treat prostate cancer.

Abiraterone Acetate is used for:

Prostate cancer, metastatic:

  • Treatment of metastatic, castration-resistant prostate cancer 
  • Treatment of metastatic, high-risk castration-sensitive prostate cancer

Zytiga prostate cancer - Abiraterone Acetate

Abiraterone Acetate Mechanism of Action:

Abiraterone selectively and irreversibly inhibits CYP17 , an enzyme required for androgen biosynthesis which is expressed in testicular, adrenal, and prostatic tumor tissues. Inhibits the formation of the testosterone precursors dehydroepiandrosterone (DHEA) and androstenedione.

Dosing of Abiraterone Acetate:

Adults:Zytiga: 1,000 mg once daily (in combination with prednisone 5 mg twice daily)

Yonsa (micronized formulation): 500 mg once daily (in combination with methylprednisolone 4 mg twice daily)

Doesn’t require dose adjustment for renal patients.

Patients with currently hepatic impairment; it depends on the severity of the liver status:Mild: No dosage adjustment necessary.Moderate : 250 mg once daily (Zytiga) or 125 mg once daily (Yonsa). Permanently discontinue if ALT and/or AST >5 times the ULN or total bilirubin >3 times ULN occur during treatment in patients with baseline moderate hepatic impairment.Severe: Do not use.

Ref.BNFLexicomp – Drug information handbook