Docusate

About Docusate:

It’s a stool softener medication that is used in prevention of straining during defecation and constipation associated with hard, dry stools; relief of occasional constipation.

Docusate is used for:

• Constipation.
• Ear wax removal.

sodium;1,4-bis(2-ethylhexoxy)-1,4-dioxobutane-2-sulfonate

Docusate Mechanism of Action:

Abiraterone selectively and irreversibly inhibits CYP17 , an enzyme required for androgen biosynthesis which is expressed in testicular, adrenal, and prostatic tumor tissues. Inhibits the formation of the testosterone precursors dehydroepiandrosterone (DHEA) and androstenedione.

Dosing of Docusate:

Adults:​Zytiga: 1,000 mg once daily (in combination with prednisone 5 mg twice daily)​

Yonsa (micronized formulation): 500 mg once daily (in combination with methylprednisolone 4 mg twice daily)

Doesn’t require dose adjustment for renal patients.

Patients with currently hepatic impairment; it depends on the severity of the liver status:Mild: No dosage adjustment necessary.Moderate : 250 mg once daily (Zytiga) or 125 mg once daily (Yonsa). Permanently discontinue if ALT and/or AST >5 times the ULN or total bilirubin >3 times ULN occur during treatment in patients with baseline moderate hepatic impairment.Severe: Do not use.

Ref.BNFLexicomp – Drug information handbook