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Hereditary Transthyretin-Mediated Amyloid Polyneuropathy (ATTRv-PN) is a rare, progressive, and often fatal genetic disease caused by mutations in the transthyretin (TTR) gene. It results in the accumulation of amyloid fibrils in the nerves, heart, and other organs, leading to symptoms such as polyneuropathy and cardiomyopathy, as well as other serious complications.