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FORTIFIED EYE DROPS

“How to create a fortified eye drop?”

- Some answers here

Fortified Eye Drop

Materials Needed

Procedure

Fluconazole eye drops 2mg/ml

1 vial Fluconazole 2mg/ml

1 bottle Tears Naturale eye drops

10CC syringe

1.Discard Tears Naturale content.

2.Put 10ml of Fluconazole soln. into the empty bottle.

3.Label the bottle properly.

Fortified Gentamicin 15mg/ml

1 bottle Gentamicin (0.3%) E.D.

1 amp.Gentamicin 80mg/2ml

2 pieces 3CC syringes

1. Add the 2 ml of Gentamicin amp.(80mg) to 4 ml of Gentamicin eye drops.

2. Label the bottle properly.

Fortified Amikacin 20mg/ml

1 amp.Amikacin 100mg/2ml

1 bottle tears natural E.D.

1 piece 10CC syringe

1 piece 3CC syringe

1. Discard 12 ml of tears naturalE.D.

2. Add the 2 ml Amikacin to the remaining 3 ml of tears natural E.D. 

3. Label the bottle properly

Fortified Cefuroxime 50mg/ml

1 vial Cefuroxime 750mg (Zinacef 750mg)

1 amp. water for injection

1 bottle tears natural E.D.

2 pieces 3CC syringe

1. Dilute Cefuroxime with 2.5 ml sterile water

2. Discard 2.5 ml of teras natural E.D.

3. Add the diluted Cefuroxime to the remaining 12.5 ml tears natural E.D.

4. Label the bottle properly 

Fortified Cefazolin/Ceftazidime 50mg/ml

1 vial Cefazolin/Ceftazidime 500mg

1 amp water for injection

1 bottle tears natural E.D.

1 piece 10CC syringe

1 piece 3CC syringe 

1. Dilute the antibiotic with 2.5 ml sterile water

2. Discard 7.5 ml of teras natural E.D.

3. Add the diluted antibiotic to the remaining 7.5 ml of tears natural E.D.

4.Label the bottle properly

Fortified Vancomycin 50mg/ml

1 vial Vancomycin 0.5 gm

1 amp water for injection

1 bottle teras natural E.D.

1 piece 10CC syringe

1. Dilute Vancomycin with 10 ml sterile water

2. Discard all the content of tears natural E.D.

3. Put the diluted Vancomycin into the empty bottle of tears natural E.D.

4. Label the bottle properly

Cyclosporine Eye Drop 10mg/ml

1 capsule Cyclosporine 100mg

1 bottle teras natural E.D.

1 piece disposable needle

1. Pick the capsule with sterile needle 

2. Mix the content of the capsule with 10 ml tears natural E.D.

3. Label the bottle properly

Anti-vascularization Treatment

2 bottle tears natural E.D.

4 vials Kenacort 40mg/ml

2 capsules Doxydar (Tabocine 100mg)

1. Add 4 ml of Kenacort to 4 ml of tears natural E.D.

2. Add the content of 2 capsule of Doxydar to 10 ml of tears natural E.D.

3. Label the two bottle properly 

EXPIRATION DATE: 24 HOURS AT ROOM TEMPERATURE, 96 HOURS IN REFRIGERATOR.

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Can KCL and MgSO4 be mixed together?

Can kcl and mgso4 be mixed together?

Today Pharmacy received an order for electrolytes (kcl and mgso4). the patient had severe electrolytes imbalance and the ICU physician ordered some corrective measures.

The order came as follows:
[20MEQs of KCL + 2GM of MgSO4] mixed to 200ML of D5W in 0.45% NACL.

Our pharmacy stock of Potassium chloride is from PSI factory in Jeddah, and it comes as 20MEQs in 10ML, Magnesium sulphate comes as 2.5GM in 5ML. The needed preparation was supposed to be mixed as follow:

  1. 1
    10ML of KCL that gives 20MEQs.
  2. 2
    4ML of MgSO4 that gives 2GM.
  3. 3
    186ML of D5W 0.45% NACL.

Physical Compatibility: Physically compatible. No visible haze or particulate formation, color change, or gas evolution.
Chemical Stability: Chemically stable. Less than 5% change in measured potassium and magnesium concentrations occurred in 24 hours.
Storage: Room temperature of 22 °C.

Reference:

Quay I, Tan E: Compatibility and stability of potassium chloride and magnesium sulfate in 0.9% sodium chloride injection and 5% dextrose injection solutions. Int J Pharmaceut Compound: 2001. 5: 323-4.
https://www.ncbi.nlm.nih.gov/pubmed/23981924

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