Some key points to keep in mind while preparing ADO-TRASTUZUMAB EMTANSINE:
Some infusion reactions are documented with few cases. If it happened, then either stop the infusion or set the rate as slow as possible. Infusions should be over 90 minutes for the first dose, and if the patient tolerated the dose, then infusion for the following doses can be over no less than 30 minutes. (However, I always advise our nursing staff to always go for the 90 minutes.)
Depending on the reaction type of the reaction severity, the dose should be decreased and patient status is to be monitored, as mentioned, the regular dose is 3.6mg per kg, If this dose induced some reaction/toxicity, next dose should be 3mg per kg, and the following dose is 2.4mg per kg if another reaction took place with the first dose adjustment, however if the reaction still not controlled with the second dose reduction, the treatment should be discontinued and alternative therapy should be pursued.
Check the patient for allergic reaction. Review the labs for liver enzymes. Monitor symptoms for heart failure.