Medications Used in Extravasation Kits

Dexamethasone or hydrocortisone

would suppress the local inflammation caused by tissue trauma that occurs during the treatment process.


is an enzyme responsible for degrading hyaluronic acid and this enhances the systemic uptake of the medication. It is used with vinca-alkaloids and paclitaxel.

Dimethylsulfoxide (DMSO)

enhances skin permeability thus facilitating the systemic absorption of the vesicant drug. It has also free radical scavenging properties. Air-drying is required as DMSO may cause blisters if occluded. Should avoid contact with undamaged tissue.

Sodium thiosulphate

directly deactivate chlormethine (mustine).


Pharmacist, CPHQ, CHQO, Quality Coordinator, Chemotherapy Preparation incharge. Graduated pharmacy school in 2009 I stood with my classmates as we recited the “Oath of a Pharmacist” in. There is one particular vow that stood out to me as we recited the Oath and I embrace this vow, “I will apply my knowledge, experience, and skills to the best of my ability to assure optimal outcomes for my patients.” I love being a pharmacist because it allows me to use my knowledge, abilities, and talents to improve patient outcomes in the community hospital in which I am employed as the pharmacy clinical coordinator.

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