Dexamethasone or hydrocortisone

would suppress the local inflammation caused by tissue trauma that occurs during the treatment process.

Hyaluronidase

is an enzyme responsible for degrading hyaluronic acid and this enhances the systemic uptake of the medication. It is used with vinca-alkaloids and paclitaxel.

Dimethylsulfoxide (DMSO)

enhances skin permeability thus facilitating the systemic absorption of the vesicant drug. It has also free radical scavenging properties. Air-drying is required as DMSO may cause blisters if occluded. Should avoid contact with undamaged tissue.

Sodium thiosulphate

directly deactivate chlormethine (mustine).