June 30, 2017
Proton pump inhibitors inhibit gastric acid secretion by blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the ‘proton pump’) of the gastric parietal cell. Proton pump inhibitors are effective short-term treatments for gastric and duodenal ulcers; they are also used in combination with antibacterials for the eradication of Helicobacter pylori In patients with peptic ulcer bleeding, treatment with a proton pump inhibitor reduces the risk of rebleeding and the need for surgery.