It works by catalyzing the deamidation of asparagine to aspartic acid and ammonia, reducing circulating levels of asparagine. This makes leukemia cells unable to synthesize asparagine. […]
Usual dosing HCO3 needed (mEq) = 0.3 x Wt (kg) x base deficit (mEq/L)Administer half of calculated dose, and then assess need for remainder Usual dosage […]