Our nephrologists wants to use injection streptokinase to restore patency to thrombosed hemodialysis catheter and they dilute one vial of 75000 iu in 100 ml normal saline or water for injection then use 3 ml only and the remaining is discarded.
In our hospital we prepare ALTEPLASE in conc of 2mg/2ml stored in freezer to clear occluded venous catheter, which is stable for 6 months.
A regimen of alteplase is safe and effective for restoring flow to occluded central venous access devices compared to streptokinase because of the risk of life-threatening anaphylaxis.
Personally, I prefer the use of Alteplase over Streptokinase for the following reasons:
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We have alteplase in the freezer for 6 months also.
each 50mg vial gives 25 syrings. 2mg each.