Abacavir Vs Lamivudine – Alerts, ADR and Dosing
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MedicationComparison
Brand NamesWithin the states
Ziagen
VS
Epivir
AlertBoxed warnings
Hypersensitivity reactions
VS
​Exacerbations of hepatitis B
AdministrationOral
With or without food
VS
With or without food
ADRTop 10%
Mostly Central (CNS) and Gastrointestinal
VS
Mostly Central (CNS) and Dermatologic
Contraindications Avoid
Hypersensitivity, patients who are positive for the HLA-B*5701 allele and moderate to severe hepatic impairmentÂ
VS
HypersensitivityÂ
DosingAdult
300 mg twice daily or 600 mg once daily
VS
[HIV-1 infection]
150 mg twice daily or 300 mg once daily
[Hepatitis B]
100 mg once daily
[Hepatitis B/HIV coinfection]
150 mg twice daily or 300 mg once daily
150 mg twice daily or 300 mg once daily
[Hepatitis B]
100 mg once daily
[Hepatitis B/HIV coinfection]
150 mg twice daily or 300 mg once daily
ExcretionÂ
Urine
VS
Urine, majority as unchanged drug
Half-Life Elimination
12 to 26 hours
VS
10 to 15 hours
MetabolismElimination
HepaticÂ
VS
Minor
MOAMechanism of action
Inhibition of viral replication
VS
Inhibition of HIV reverse transcription.
Incorporated into the viral DNA by hepatitis B virus polymerase, resulting in DNA chain termination
Incorporated into the viral DNA by hepatitis B virus polymerase, resulting in DNA chain termination
Pregnancy
Use cautiously
VS
Use cautiously
Breast-FeedingLactation
Not recommended
VS
Not recommended
General precautions for both abacavir and lamivudine
- Consumption of alcoholic beverages may increase the plasma concentrations an pharmacologic effects of Abacavir.
- No Drug-Food Interactions information found for Abacavir or lamivudine.
- Patient may be at increased risk for lactic acidosis, severe hepatomegaly with steatosis, and/or hepatic failure.
