Patient using Coversyl + Celebrex

Decreasing Prostaglandins by inhibiting COX-2. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) with normal doses.

CELECOXIB MOA

How celecoxib works


when angiotensin 1 is converted to angiotensin 2, it results in strong vasoconstriction.

Perindopril prevents conversion of ang1 to ang2, but blocking Angiotensin converting Enzyme (ACE)

CELECOXIB MOA

How Perindopril works


Coversyl may enhance the adverse/toxic effect of Celebrex. The combination of Celebrex and Coversyl may result in a significant decrease in renal function. Celecoxib may diminish the antihypertensive effect of coversyl.

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