Decreasing Prostaglandins by inhibiting COX-2. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) with normal doses.
How celecoxib works
when angiotensin 1 is converted to angiotensin 2, it results in strong vasoconstriction.
Perindopril prevents conversion of ang1 to ang2, but blocking Angiotensin converting Enzyme (ACE)
How Perindopril works
Coversyl may enhance the adverse/toxic effect of Celebrex. The combination of Celebrex and Coversyl may result in a significant decrease in renal function. Celecoxib may diminish the antihypertensive effect of coversyl.