Decreasing Prostaglandins by inhibiting COX-2. Celecoxib does not inhibit cyclooxygenase-1 (COX-1) with normal doses.


How celecoxib works

when angiotensin 1 is converted to angiotensin 2, it results in strong vasoconstriction.

Perindopril prevents conversion of ang1 to ang2, but blocking Angiotensin converting Enzyme (ACE)


How Perindopril works

Coversyl may enhance the adverse/toxic effect of Celebrex. The combination of Celebrex and Coversyl may result in a significant decrease in renal function. Celecoxib may diminish the antihypertensive effect of coversyl.

Tagged in: