Dopaminergic Post

how dopamine works?

Dopamine works on both adrenergic and dopaminergic receptors, starting from lower dosing, as you go up effects on adrenergic receptors starts to predominate.

LOWER DOSES
Mainly dopaminergic, working on renal and mesenteric vasodilation

HIGHER DOSES
Same as lower doses, but with beta1-adrenergic action and produce cardiac stimulation; larger doses stimulate alpha receptors

DOSE (ADULT)

ACTION

Low dose
1 to 5 mcg/kg/minute

increased renal blood flow and urine output

Intermediate dose
5 to 10 mcg/kg/minute

same as lower dosing + increased heart rate, cardiac output and contractility

High dose
10 mcg/kg/minute

same as intermediate dosing + vasoconstriction thus increased blood pressure

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