Question number one
When treating patients with Helicobacter pylori infection who have previously been exposed to macrolides, which treatment approach does the American College of Gastroenterology (ACG) recommend?
- Clarithromycin-based triple treatment is recommended.
- A proton pump inhibitor (PPI) and amoxicillin are used to treat the infection.
- Bismuth quadruple therapy is a kind of treatment.
- Amoxicillin is used in a high-dose dual regimen.
Question number two
The presence of significant levels of antibiotic resistance, along with treatment failure, has rendered conventional first-line therapy for the treatment of Helicobacter pylori infections unsuitable in many areas.
Question number three
The patients in a recent Phase 3 trial evaluating three different first-line treatments for H. pylori infection were randomized to one of three treatments: vonoprazan with amoxicillin (dual P-CAB), vonoprazan with amoxicillin and clarithromycin (triple P-CAB), or lansoprazole with amoxicillin and clarithromycin (triple P-CAB) (triple lansoprazole). As opposed to lansoprazole, which of the following statements better characterizes the P-CAB regimens:
- The effectiveness of dual P-CAB treatment was shown to be inferior to that of triple P-CAB therapy and triple lansoprazole therapy.
- The use of triple lansoprazole was shown to be better to the use of dual P-CAB treatment.
- Each of the P-CAB regimens was shown to be non-inferior to triple lansoprazole treatment.
- The use of triple lansoprazole was shown to be superior to both P-CAB regimens.