Generic Name : Carbidopa/Levodopa (Sinemet®) Indication : Parkinson’s disease Dosage Form : Suspension Strength : 1.25mg Carbidopa/5mg Levodopa/mL Stability : 42 days if refrigerated or 28 days at room temperature Storage : Refrigerate (preferred) or at room temperature and protect from light
INGREDIENTS: Sinemet ® 25mg/100mg 5 tablets Vehicle qs 100 mL
VEHICLE OF CHOICE: • Ora-Sweet® : Ora-Plus® (1:1) or • Ora-Blend ® or • Equivalent vehicle to Ora-Sweet® : Ora-Plus® (1:1)
How to prepare CARBIDOPA/LEVODOPA (SINEMET®) SUSPENSION 1.25MG CARBIDOPA/5MG LEVODOPA/ML: 1. Crush tablets in a mortar to fine powder. 2. Levigate the powder with small amount of vehicle until smooth paste is formed. 3. Add more vehicle to the paste until liquid is formed and transfer the liquid into a container. 4. Use additional vehicle to rinse the remaining drug from the mortar and pour into the container. 5. Make up to final volume with vehicle. 6. Shake well and label.
NOTES: 1. Suspension stored at room temperature may change colour to darker yellow.