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What is Doxorubicin Transarterial Chemoembolization (TACE)?
Doxorubicin is a medication used to treat patients with hepatocellular carcinoma (HCC). The drug acts against the enzyme that is believed to be responsible for the formation of tumors in the liver. In addition, it has been shown to cause a reduction in the size of tumors once the drug is introduced.
Known as doxorubicin chemoembolization.
To answer the question, “Doxorubicin embolization for doxorubicin for hepatocellular carcinoma,” several issues must be considered. The primary concern is whether or not the patient will require a transplant of the liver, as well as whether or not the patient will develop rejection of the transplant.
Another concern is the amount of time the treatment will take to give the patient a new life. Lastly, the cost of the treatment, which can range from several thousand dollars to tens of thousands of dollars, must also be considered. Some insurance companies cover some of the cost of doxorubicin treatment for patients with certain types of liver cancer, but not all do so.
As noted above, doxorubicin embolization for doxorubicin for hepatocellular carcinoma is used primarily in patients who do not respond or who have a very poor prognosis. However, this treatment is sometimes used in other circumstances where doxorubicin is indicated, especially in patients who have resevascularized cancer or who have abdominal masses. This treatment may also be used in patients who are undergoing chemo or radiation therapy, and for whom doxorubicin is administered via injection.
Other effects of doxorubicin chemoembolization.
In recent years, researchers have become aware that doxorubicin may also be effective in the treatment of patients who have cirrhosis, although the results of these studies are still inconclusive. Cirrhosis is a chronic liver disease in which scar tissue forms inside the organ.
The scar clogs the flow of blood through the liver, causing the organ to function less efficiently and to undergo numerous processes. In most patients, doxorubicin embolization for doxorubicin for hepatocellular carcinoma is effective in reversing or greatly reducing the effects of cirrhosis, making it an ideal treatment for patients with this type of liver cancer. However, this treatment is not recommended for patients with chronic liver disease, as it can be very toxic to the liver.
Doxyribonucleoside analogs (DNA) is an alternative doxorubicin injection for patients with moderate to severe hepatic cirrhosis who also have anemia and other negative symptoms, such as fever. Clinical trials evaluating doxorubicin for hepatocellular carcinoma and other forms of hepatocellular carcinoma are currently being conducted.
A phase I clinical trial comparing doxorubicin with doxorubicin hydrochloride showed no significant difference in the rate of progression of liver tumors, although the patients in the doxorubicin group did have a higher incidence of acute liver failure at the end of the study.
In a phase IIb study of doxorubicin for hepatocellular carcinoma, there was a significant positive effect on patients with moderate to severe hepatic cirrhosis but with a history of previous liver disease. In a phase III clinical trial of doxorubicin for the treatment of patients with cirrhosis and liver cancer, there were no significant differences between patients receiving doxorubicin hydrochloride.
There are some drug safety precautions in patients receiving doxorubicin as treatment for hepatocellular carcinoma or other types of cancer. Patients should be under the care of their physician and not begin any regular medication or treatment without first consulting with the physician. Patients should use non-steroidal anti-inflammatory medications while on doxorubicin embolization for prevention of symptoms.
Hepatitis C
Patients should stop taking doxorubicin hydrochloride after the initial chemotherapy treatment. Patients with chronic Hepatitis C should be closely monitored and treated if they develop a flare-up of symptoms. Some patients may need to be regularly monitored to prevent the risk of doxorubicin toxicity. Patients and their physicians can further discuss the benefits and risks of doxorubicin when in the post-operative care setting.
It is not known whether doxorubicin is better tolerated by younger or older patients. Dosage and administration of doxorubicin should be carefully calculated and monitored according to specific needs. Although it is usually administered intravenously, doxorubicin may also be given orally. To maximize the effectiveness of doxorubicin, patients should be given the full dose at the beginning of each treatment cycle.
Doxorubicin chemoembolization possible side effects
It is important for patients considering doxorubicin embolization to be aware of possible side effects, including vomiting, drowsiness, joint pain, increased appetite and cold symptoms. Patients should notify their physician if they experience these symptoms. The patient should be advised of the risks and side effects of doxorubicin hydrochloride and the benefits of complete lung recovery. Patients should also be informed about the side effects of other drugs, if present, which may be reduced with doxorubicin.
