Mepredine

Viewing 1 reply thread
  • Author
    Posts
    • #48455

      Michele
      Guest

      hi there,
      Why can’t a patient use Mepredine for long time?

    • #48456

      TDP
      Keymaster

      Hello,

      short answer is neurotoxicity.

      Normeperidine (an active metabolite and CNS stimulant) may accumulate and precipitate anxiety, tremors, or seizures; risk increases with preexisting CNS or renal dysfunction, prolonged use (>48 hours), and cumulative dose (>600 mg/24 hours in adults). Oral meperidine should not be used since first-pass metabolism decreases efficacy while increasing normeperidine concentrations (APS 2016). Note: Naloxone does not reverse, and may even worsen, neurotoxicity.

Viewing 1 reply thread

You must be logged in to reply to this topic.

Mepredine
This website uses cookies to improve your experience. By using this website you agree to our Cookie Policy.
Read more