I echo to Heather in her opinion. We use the same practice for the same reason. Kindly find the below link.
The FDA review you have included actually refers to BA resulting into gasping syndrome in doses > 99 mg/kg/day in neonates and low birth weight preterm infants:
“Benzyl Alcohol Toxicity
The statement about the amount that causes the toxicity is unknown as in subsequent section of the FDA’s review this is mentioned. However I would like to highlight the background of this problem. Back in the 80s, a number of neonatal fatalities were attributed to BA toxicity, however that was in a setting where routine line flushing with heparinized fluid that also contained a bacteriostatic and had BA in concentration of 9 mg/mL. I quote the CDC’s report in 1982:
“Review of the medical records of the affected infants resulted in estimates of daily intake of benzyl alcohol ranging from 99 to 405 mg/kg/day. Based on these reports, the FDA has recommended that intravascular flush solutions containing benzyl alcohol not be used for newborns and that diluents with this preservative not be used as medications for these infants.”
I think that this practice is not common now in the clinical setting. However you always weight the risk according to your setting.
You must be logged in to reply to this topic.