Crystals Mannitol Infusion

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    • #49031
      Frank Morgan
      Participant

      Very quick question
      Found crystalized particles in mannitol while infusing
      Shall we discontinue?
      Or else?

    • #49035
      Alchemist
      Participant

      Hello, get a new bag and start infusing again if there are a significant amount of crystals. I recommend getting a new bag since the mannitol is crystalizing = necessary drug that is now no longer available to give to the patient. Perhaps withdraw the amount already infused from the new bag before starting, or set your IV pump to only infuse the remainder that would be needed.

      Many times to reduce chance of crystallization I will convert orders from 25% to 20% mannitol, but it can still happen.

      Ensure you always infuse mannitol through a filter (usually a filter needle which is 5 micron in size is adequate) in case that happens.

    • #49034
      Debra Cook
      Participant

      I agree with Alchemist’s comment, where you currently store or stock your bags of Mannitol 20% is essential also, it will be great if you have a warmer in your pharmacy department to prevent that from happening.

    • #49036
      Naveed Rivas
      Participant

      Usually mannitol crystalize when exposed at lower temperature especially at higher concentrations so if it is prior administration , you shall warm it to 37°C and followed by gentle agitation but if it is happened during administration so in this case you shall change the bag and you need to use always inline filter

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