Could Atropine Sulphate eye drops 1% be diluted to 0.01% ?

[Patricia Taylor]

I have a query raised by the Ophthalmologist about Atropine Sulphate eye drops 1%.
Could Atropine Sulphate eye drops 1% be diluted to 0.01%?

If this is possible to be done, kindly share your experience and advice about the diluent and the protocol.

Thanks a lot.

[Alchemist]

Yes, it can be and below is the recipe

Equipment:
1 mL TB syringe Quantity: 2

Procedure:
1. Remove 0.15 mL from tears naturalle II 15 mL bottle
2. Using 1 mL TB syringe withdraw 0.15 mL from Atropnie 1% and add to tears naturale II bottle
3. Slowly draw up tears natural from bottle into same syring to rinse Atropine into bottle
4. Replace the cap and label

Storage: Refrigerate
Expiration: 14 days

References:
Dr. Paul Rychwaslski
Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5 %, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2) https://www.sciencedirect.com/science/article/abs/pii/S0161642011006853

[Patricia Taylor]

Thanks a lot for the recipe.

please advise if this can be done in ISO 5 Laminar flow located in ISO 7 clean room?

[Alchemist]

Yes, it should be done ISO 5 Laminar flow located in ISO 7 clean room

[Author]

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