Could Atropine Sulphate eye drops 1% be diluted to 0.01% ?

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    • #49322
      Patricia Taylor
      Participant

      I have a query raised by the Ophthalmologist about Atropine Sulphate eye drops 1%.
      Could Atropine Sulphate eye drops 1% be diluted to 0.01%?

      If this is possible to be done, kindly share your experience and advice about the diluent and the protocol.

      Thanks a lot.

    • #49323
      Alchemist
      Participant

      Yes, it can be and below is the recipe

      Equipment:
      1 mL TB syringe Quantity: 2

      Procedure:
      1. Remove 0.15 mL from tears naturalle II 15 mL bottle
      2. Using 1 mL TB syringe withdraw 0.15 mL from Atropnie 1% and add to tears naturale II bottle
      3. Slowly draw up tears natural from bottle into same syring to rinse Atropine into bottle
      4. Replace the cap and label

      Storage: Refrigerate
      Expiration: 14 days

      References:
      Dr. Paul Rychwaslski
      Atropine for the Treatment of Childhood Myopia: Safety and Efficacy of 0.5 %, 0.1%, and 0.01% Doses (Atropine for the Treatment of Myopia 2) https://www.sciencedirect.com/science/article/abs/pii/S0161642011006853

    • #49324
      Patricia Taylor
      Participant

      Thanks a lot for the recipe.

      please advise if this can be done in ISO 5 Laminar flow located in ISO 7 clean room?

    • #49325
      Alchemist
      Participant

      Yes, it should be done ISO 5 Laminar flow located in ISO 7 clean room

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