We are using the preservative-free Heparin Sodium Injection in neonates and infants (Porcine source) . The cause is that the “preservative benzyl alcohol” has been associated with serious adverse events and death in pediatric patients. The minimum amount of benzyl alcohol at which toxicity may occur is not known. Premature and low-birth weight infants may be more likely to develop toxicity!
From my experience at 3 different tertiary hospitals in Riyadh, we all use the preservative free heparin in neonatal/ pediatric TPN.
