CYCLOPHOSPHAMIDE PROTOCOL FOR RPGN

  • ONE HOUR PRIOR THE INFUSION HYDRATES WITH 500CC NORMAL SALINE FOR ONE HOUR.
  • HALF AN HOUR PRIOR THE INFUSION GIVE:-
  • ONDANSETRON 8MG TAB (ONE TAB.) STAT
  • MESNA(UROMETEXAN) 200MG IN 100CC NORMAL SALINE IV OVER 30 MIN.
  • CYCLOPHOSPHAMIDE(ENDOXAN) INFUSION AS FOLLOW:
    1000MG + MESNA 400 MG IN 500CC NORMAL SALINE TO BE INFUSED OVER ONE HOUR.

(DOSE OF CYCLOPHOSPHAMIDE IS 0.75GM/M²  BSA ).

  • FOLLOWING CYCLOPHOSPHAMIDE INFUSION, HYDRATE WITH 500CC NORMAL SALINE FOR ONE HOUR.

Cyclophosphamide

Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis. It is a cell cycle phase nonspecific agent. Cyclophosphamide also possesses potent immunosuppressive activity. Cyclophosphamide is a prodrug that must be metabolized to active metabolites in the liver.

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