MESNA(UROMETEXAN) 200MG IN 100CC NORMAL SALINE IV OVER 30 MIN.
CYCLOPHOSPHAMIDE(ENDOXAN) INFUSION AS FOLLOW:1000MG + MESNA 400 MG IN 500CC NORMAL SALINE TO BE INFUSED OVER ONE HOUR.
(DOSE OF CYCLOPHOSPHAMIDE IS 0.75GM/M² BSA ).
FOLLOWING CYCLOPHOSPHAMIDE INFUSION, HYDRATE WITH 500CC NORMAL SALINE FOR ONE HOUR.
Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis. It is a cell cycle phase nonspecific agent. Cyclophosphamide also possesses potent immunosuppressive activity. Cyclophosphamide is a prodrug that must be metabolized to active metabolites in the liver.