CYCLOPHOSPHAMIDE PROTOCOL FOR RPGN
(DOSE OF CYCLOPHOSPHAMIDE IS 0.75GM/M² BSA ).
Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and decreasing DNA synthesis. It is a cell cycle phase nonspecific agent. Cyclophosphamide also possesses potent immunosuppressive activity. Cyclophosphamide is a prodrug that must be metabolized to active metabolites in the liver.