SMOFlipid has the advantage of containing 15% omega 3 fatty acids. those serve to decrease severity of Parenteral Nutrition Associated Liver Disease, PNALD also known as cholestatic jaundice, in long term PN dependant patient. Intralipid of course does not have this advantage, there are no precautions at this shift really, I’m assuming you are faced with the shortage for a limited time. however I you have long term PN dependant babies, like those with short bowel syndrome, you might want to try and give at least 1 gram of their lipids as omega 3 fatty acids. the product I know about is Omegaven, which is 100% omega 3 fatty acids emulsion for IV.