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[Walter Collins]

From Micromedex

Important Note
The single 32-mg IV dose is no longer an approved dose because of the risk of QT-interval prolongation and torsades de pointes. Maximum single IV dose is 16 mg

General Dosage Information
Ondansetron hydrochloride tablets and oral solution are bioequivalent and interchangeable

Chemotherapy-induced nausea and vomiting, Initial and repeat courses of highly emetogenic chemotherapy; Prophylaxis
0.15 mg/kg IV starting 30 minutes prior to chemotherapy, repeat 4 and 8 hours after the first dose; MAX single IV dose 16 mg
24 mg orally 30 minutes prior to chemotherapy

Chemotherapy-induced nausea and vomiting, Initial and repeat courses of moderately emetogenic chemotherapy; Prophylaxis
0.15 mg/kg IV infusion over 15 minutes starting 30 minutes prior to chemotherapy, repeat 4 and 8 hours after the first dose; MAX single IV dose 16 mg
8 mg orally 30 minutes prior to chemotherapy and repeat in 8 hours, then 8 mg every 12 hours for 1 to 2 days postchemotherapy

Drug-induced nausea and vomiting
8 mg OR 16 mg IV once daily (off-label dosage)

Hyperemesis gravidarum
10 mg IV administered over 30 minutes every 8 hours (off-label dosage)
8 mg IV twice daily (off-label dosage)

Injection site pain
4 mg IV pretreatment (off-label dosage)

Irritable bowel syndrome with diarrhea
Initial, 4 mg orally once daily; may titrate up to 8 mg orally 3 times per day as needed (off-label dosage)

Multiple sclerosis – Nausea
8 mg orally twice daily (off-label dosing)

Panic disorder
1 to 2 mg IV twice daily (off-label dosage)

Postoperative nausea and vomiting; Prophylaxis
4 mg IV/IM undiluted immediately prior to anesthesia induction or postoperatively; a second dose does not provide additional benefit
16 mg orally 1 hour before anesthesia induction

Pruritus
(Cholestatic itching) 8 mg orally once daily for first day and twice daily for 6 additional days (off-label dosage)
(Palmoplantar pruritus) 8 mg orally once daily. May reduce to once weekly (off-label dosage; Downs et al 1998).
(Morphine-induced) 4 mg IV or orally given once (off-label dosage)

Radiation-induced nausea and vomiting; Prophylaxis
Single high-dose fraction or daily fractionated radiotherapy to abdomen: 8 mg orally 1 to 2 hours prior to radiotherapy and every 8 hours after first dose for 1 to 2 days.
Total body irradiation radiotherapy: 8 mg orally 1 to 2 hours prior to each fraction of radiotherapy.

Schizophrenia, Refractory; Adjunct
4 to 8 mg orally once daily as an adjunct treatment (off-label dosage)

Shivering, Postanesthesia; Prophylaxis
4 mg or 8 mg IV once, usually before induction of anesthesia (off-label dosage)