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Mechanism Of Action
Major Side Effects
As Antiviral, It appears to primarily prevent the release of infectious viral nucleic acid into the host cell by interfering with the transmembrane domain of the viral M2 protein. Amantadine is also known to prevent viral assembly during replication. It inhibits the replication of influenza A virus isolates from each of the subtypes (ie, H1N1, H2N2 and H3N2), but has very little or no activity against influenza B virus isolates.
Orthostatic hypotension, Dizziness, Xerostomia and constipation
Inhibition of production and release of interleukin II and inhibits interleukin II-induced activation of resting T-lymphocytes.
systemic hypertension and nephrotoxicity
Hypertension ,tremors ,cramps ,increased serum creatinine and hyperkalemia
Doxorubicin inhibits DNA and RNA synthesis by intercalating between DNA base pairs causing steric obstruction and inhibits topoisomerase-II at the point of DNA cleavage. Doxorubicin is also a powerful iron chelator. The iron-doxorubicin complex can bind DNA and cell membranes, producing free hydroxyl (OH) radicals that cleave DNA and cell membranes. Active throughout entire cell cycle. Doxorubicin liposomal is a pegylated formulation which protects the liposomes, and thereby increases blood circulation time.
Myocardial toxicity and Infusion reactions.
Cardiomyopathy, Fatigue, headache and Nausea
Binds to opioid receptors in the CNS, causing inhibition of ascending pain pathways, altering the perception of and response to pain; produces generalized CNS depression
Life-threatening respiratory depression, neonatal opioid withdrawal syndrome, addiction, abuse, and misuse.
Drowsiness, headache, constipation, nausea, vomiting and Urinary retention
Olaratumab is a human (recombinant) IgG1 antibody which expressly binds to platelet-derived growth receptor alpha (PDGFR-α) to prevent binding of PDGF-AA, PDGF-BB, and PDGF-CC and block receptor activation and disrupt PDGF receptor signaling. The PDGF-alpha receptor has a role in cell differentiation, growth, and angiogenesis and has demonstrated antitumor activity in sarcomas
Fatigue, headache, Hyperglycemia, hypokalemia, Nausea and diarrhea
British National Formulary
Drug information Handbook - Lexicomp
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