Adverse Drug Reactions MCQs

Adverse Drug Reactions


Question 1

Which one of the following drugs is least likely to cause drug induced blood dyscrasia or agranulocytosis?
  • A. Clozapine.
  • B. Methotrexate.
  • C. Aminosalicylates such as sulfasalazine.
  • D. Phenytoin.
  • E. Carbimazole.

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Question 2

Which of the following statements about clozapine is/are not TRUE?

I. It is used as a first line therapy in the treatment of psychosis.

II. It is used in refractory patients.

III. Patients must agree to carry out weekly blood tests while being treated with the drug.
  • A. I only.
  • B. I and II only.
  • C. II and III only.
  • D. III only.
  • E. All of these options.

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Question 3

Which of the following is the main danger caused by acetaminophen (Paracetamol, Tylenol) overdose?
  • A. Cardiac failure.
  • B. Hepatic failure.
  • C. Renal failure.
  • D. Brain damage.
  • E. None of these options.

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Question 4

Which of the following is the antidote for the toxin Lead?
  • A. Dialysis.
  • B. Nitrite.
  • C. Naloxone.
  • D. CaEDTA.

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Question 5

Which of the following drug should not be taken on empty stomach?
  • A. Cloxacillin.
  • B. Rifampicin.
  • C. Cefuroxime Axetil.
  • D. Sucralfate.
  • E. All of these options.

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Question 6

Which of the following counselling points would NOT be appropriate when talking to a patient about their azathioprine tablets?
  • A. You will need regular blood tests while taking this medication.
  • B. You should avoid coming into contact with anyone with chicken pox.
  • C. You should inform you doctor if you develop an unexplained rash.
  • D. You may feel drowsy with this medication and if affected you should avoid driving or using machinery.

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Question 7

Which of the following are Type IV hypersensitivity reactions?
  • A. Chrons disease.
  • B. Asthma.
  • C. Chrons disease and Rhematioid arthritis.
  • D. Rheumatoid arthritis.
  • E. Asthma and Rheumatoid arthritis.

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Question 8

Some asthmatic patients exhibit aspirin sensitivity (and sensitivity to other NSAIDS). Daily administration of aspirin causes desensitization not only to aspirin also to other NSAIDS. This phenomenon is:
  • A. Nocebo.
  • B. Cross-tolerance.
  • C. Efficacy.
  • D. The placebo effect.
  • E. Potency.

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Question 9

Reversible Oligospermia is associated with which of the following drugs?
  • A. Methotrexate.
  • B. Sulfasalazine.
  • C. Spironolactone.
  • D. Cimetidine.
  • E. Hydrocortisone.

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Question 10

Opiate intoxication is characterized by which of the following?
  • A. Increased respiratory rate.
  • B. Hypotension.
  • C. Miosis.
  • D. Bradycardia.
  • E. All of these options.

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Question 11

A baby swallowed the contents of a 15g tube of nystatin. What should you do to remedy the over dosage?
  • A. Call an ambulance immediately.
  • B. Rush the child to emergency services.
  • C. Nothing as the dose is too low dose for the child to get any serious side effects.
  • D. Perform an immediate stomach lavage by giving the child lots of fluid.
  • E. Administer activated charcoal.

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Question 12

Nitroglycerin is used for the treatment of angina. A specific concern related to the long term use of this drug is which of the following?
  • A. Arthritic pain.
  • B. Development of A-V heart block when given with hydralazine.
  • C. Development of profound hypertension when given with sildenafil (Viagra).
  • D. Down regulation of receptor sites.
  • E. Tolerance developing requiring larger doses.

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Question 13

Grey baby syndrome occurs with which of the following drugs?
  • A. Doxycycline.
  • B. Penicillin.
  • C. Clarithromycin.
  • D. Chloramphenicol.

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Adverse Drug Reactions


Question 14

Following are characteristics of toxic shock syndrome, EXCEPT
  • A. diffuse macular rash.
  • B. fever/headache.
  • C. myalgia/oliguria.
  • D. increased SGOT/SGPT levels.
  • E. person to person transmission.

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Question 15

Blood tests are carried out on patients who take carbimazole, which one below is a FALSE statement?
  • A. This is so that the clinician can monitor thyroid levels.
  • B. This is so that the clinician can monitor for agranular cytosis.
  • C. This is so that the clinician can monitor for ALT.
  • D. This is so that the clinician can monitor for anaemia.
  • E. This is so that the clinician can monitor for hypoglycemia.

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Question 16

Aspirin allergy is related to?
  • A. Histamine.
  • B. Arachidonic acid.
  • C. Leukotrienes.
  • D. Bradykinin.
  • E. Serotonin.

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Question 17

Antihypertensive agents must be used with caution. The medical condition for which methyldopa is most contraindicated is:
  • A. Asthma.
  • B. Liver disease.
  • C. Mental depression.
  • D. Renal insufficiency.
  • E. Coronary insufficiency.

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Question 18

Antidote for chlorpromazine overdose is:
  • A. Naloxone.
  • B. Benztropine.
  • C. N acetylcysteine.
  • D. Ethanol.
  • E. Physostigmine.

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Question 19

Antidote for amitriptyline (Elavil) overdose is:
  • A. Naloxone.
  • B. N acetylcysteine.
  • C.Physostigmine.
  • D. Ethanol.
  • E. Atropine.

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Question 20

An alcoholic patient is being attended to in the emergency room with symptoms of alcohol toxicity. Which action should be taken?

I. infusion of multivitamin thiamine (pyridoxine 100 mg IV q day) for neurological symptoms

II diazepam for withdrawal symptoms

III phenytoin for convulsions
  • A. I, II and III.
  • B. I only.
  • C. III only.
  • D. II and III.
  • E. I and II.

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Question 21

Adverse effects of beta-2 adrenergic bronchodilators include all of the following EXCEPT:
  • A. Lethargy.
  • B. Nervousness.
  • C. Headache.
  • D. Tremulousness.
  • E. Tachycardia.

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Question 22

Adverse effect(s) of laxatives:
  • A. Dehydration.
  • B. Spastic colitis with stimulant laxatives.
  • C. Gastrointestinal obstruction with bulk forming agents.
  • D. Electrolyte disturbances (hypernatremia, hypokalemia).
  • E. All of these options.

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Question 23

Acetaminophen (Tylenol) overdose is treated with:
  • A. Naloxone.
  • B. N-acetylcysteine.
  • C. Enteric charcoal.
  • D. IV fluids.
  • E. All of these options.

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Question 24

A woman phoned you whilst running a busy afternoon clinic. She told you that her husband has swallowed 30 tablets of acetaminophen/paracetamol 325mg. What is the proper advice?
  • A. He will be all right, he should not worry and this not a serious concern.
  • B. Call drug information center for help.
  • C. Induce emesis-using ipecac.
  • D. Call the poison center to ask for advice.
  • E. Refer him to the emergency department.

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Question 25

A patient complains of headache and his blood pressure is 120/80. His medications include hydrochlorothiazide and hydralazine. Which of the following would seem most likely?
  • A. The headaches are related to hydralazine-induced agranulocytosis.
  • B. The headaches are secondary to thiazide-induced hypokalemia.
  • C. The headaches are secondary to hydralazine therapy.
  • D. The headaches are caused by an temporary increased blood pressure.
  • E. The headaches are probably unrelated to drug therapy.

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Question 26

A doctor and nurse start frantically looking for naloxone for a female patient is suspected of overdosing of IV narcotics. What basic principle in the treatment of poisoning are they overlooking?
  • A. Electrolytes.
  • B. Syrup of ipecac.
  • C. Blood analysis.
  • D. Gastric lavage.
  • E. Control of vital functions.

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Question 27

A child has ingested an unknown substance and has evidence of respiratory depression. This symptom is usually found with poisoning due to:
  • A. Amphetamines.
  • B. Kerosene.
  • C. Atropine.
  • D. Opioids.
  • E. Mushrooms.

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