How to Calculate The Dose for Prothrombin Complex Concentrate(Kcentra)

PCC is used for urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist (eg, warfarin) therapy in patients with acute major bleeding or a need for an urgent surgery/invasive procedure

Patient’s pretreatment INR and body weight determine dose

Weight-based dose: IV:

Pretreatment INR: 2 to <4: Administer 25 units/kg; maximum dose: 2,500 units.

Pretreatment INR: 4 to 6: Administer 35 units/kg; maximum dose: 3,500 units.

Pretreatment INR: >6: Administer 50 units/kg; maximum dose: 5,000 units.
When using a weight-based approach, repeat dosing is not recommended

Fixed dose: IV: 

Initial: 1,000 to 2,000 units once; for intracranial hemorrhage use, 1,500 to 2,000 units is recommended; repeat dosing has not been adequately studied and is not typically recommended unless INR reversal is inadequate

Full prescribing information


Pharmacist interested in improving the health outcome for every single case he meets.

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