Contraindications: inability to walk, acute phlebitis, oral contraceptive use, obese legs.
Dose and Administration: The usual intravenous dose is 1.5 to 5.0 mL per varix. The maximum dose per treatment session should not exceed 20 mL. Patients with significant liver dysfunction (Child Class C) or concomitant cardiopulmonary disease should usually receive less than the recommended maximum dose.
Submucosal injections are not recommended as they are reportedly more likely to result in ulceration at the site of injection.