Alpha-Adrenoceptor Blocking Drugs

Alpha-Adrenoceptor Blocking Drugs Alpha-Adrenoceptor Blocking Drugs

Terazosin:

Indications: indicated for the treatment of symptomatic benign prostatic hyperplasia (BPH). also indicated for the treatment of hypertension alone or in combination with other antihypertensive agents such as diuretics or beta­adrenergic blocking agents.

Contraindications: contraindicated in patient’s known to be hypersensitive to terazosin hydrochloride.

Dose and Administration: Benign Prostatic Hyperplasia: 1 mg at bedtime is the starting dose The dose should be increased in a stepwise fashion to 2 mg, 5 mg, or 10 mg once daily to achieve the desired improvement of symptoms and/or flow rates. Hypertension: The usual recommended dose range is 1 mg to 5 mg administered once a day; however, some patients may benefit from doses as high as 20 mg per day.

Doxazosin:

Indications: treatment of both the urinary outflow obstruction and obstructive and irritative symptoms associated with BPH. also indicated for the treatment of hypertension alone or in combination with diuretics, beta-adrenergic blocking agents, calcium channel blockers or angiotensin-converting enzyme inhibitors.

Contraindications: contraindicated in patients with a known sensitivity to quinazolines.

Dose and Administration: Benign Prostatic Hyperplasia 1–8 mg once daily. Hypertension 1–16 mg once daily.

Alfuzosin:

Indications: indicated for the treatment of signs and symptoms of benign prostatic hyperplasia. It is not indicated for the treatment of hypertension. Contraindications: contraindicated for use in patients with moderate or severe hepatic impairment, contraindicated for use with potent CYP3A4 inhibitors such as ketoconazole, itraconazole, and ritonavir.

Dose and Administration: The recommended dosage is one 10 mg once daily.

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